My dr. has recommended that I give Premarin (Ugh. I know what it is.) a six week trial run. I'm surprised that he prescribed it, considering my history. He must think, however, that it will benefit me. I'm very reluctant to take it. My track record with estrogen has been unpleasant -- depression, irritability, and weight gain. Does anyone have any experience with Premarin? I have prayed about it, but I am unclear as to what to do. The prescription has been filled, but I have yet to take any of them. I remember when I took something similar years ago, that I would start feeling the depression, irritability, and weight gain, in as little as a three or four days. I don't want to deal with any of that during Thanksgiving and Christmas.